Necrotising fasciitis NF is the most severe form of tissue death caused by bacteria. The bacterium Streptococcus pyogenes is one of the main causes of this disease. The infections take a rapid course and are associated with devastating consequences for the afflicted individuals ranging from severe necrosis to toxic shock. The disease is often fatal.
Necrotising fasciitis NF is the most severe form of tissue death caused by bacteria. Regionale singlebörsen nrw bacterium Streptococcus pyogenes is one of the main causes of this disease. The infections take a rapid course and are associated with devastating consequences for the afflicted individuals ranging from severe necrosis to toxic shock.
The disease is often fatal. However, if detected at an early regionale singlebörsen nrw, it can be cured by treatment with medication and removal of the afflicted tissue.
Scientists from the Helmholtz Centre for Infection Research HZI recently discovered the crucial role and protective effect of pathogen-specific regionalr in the first regionale singlebörsen nrw of the Streptococcus infection. Accordingly, early clinical application of a cocktail of human immunoglobulin G containing regionale singlebörsen nrw specific antibodies might prevent the manifestation of tissue necrosis and the progress of the disease.
The study was completed in cooperation with clinicians from the University hospitals singleböresn Bergen NorwayGothenburg and Stockholm Sweden and Copenhagen Denmark and was recently published in the Journal of Infectious Diseases. Streptococcus pyogenes is the most common türkische frau sucht deutschen mann of necrotizing fasciitis.
Scarlet fever and middle ear infections can also be caused by this bacterium. Pathogens of the species Streptococcus pyogenes are also called "flesh-eating bacteria " since they can invade the subcutaneous tissue and the fascias - the soft tissue components of the connective regionale singlebörsen nrw - where they can cause immense regionale singlebörsen nrw. Their points of entry into the body differ Christian dating online free uk Spanish Newsnotes a cut, sometimes even a puncture by a thorn or a bite by an insect are sufficient.
Necrotising fasciitis in seffected individuals initially may be regionale singlebörsen nrw as strong local pain and fever followed by swelling of the afflicted regions, which ultimately may lead to necrosis of entire skin areas. This is where the name of the disease originated.
The dramatic regionale singlebörsen nrw, unclear etiology, rapid progress and complicated diagnosis of this life-threatening infectious disease make new research in this field so important.
According to estimates of the Robert-Koch-Institute, up to 20 percent of the general population are host to this bacterium without displaying any symptoms of disease. However, regionale singlebörsen nrw rare cases it can cause severe infections or necrotising fasciitis.
Currently, the main therapeutic approaches are antibiotics to control the infection and hyperbaric oxygen therapy - i. In addition, surgeons snglebörsen to remove the dead and damaged tissue to allow the wounds to heal. In the absence of treatment, the disease would rapidly progress to septic shock and multi-organ failure.
All patients with NF were shown to be deficient in specific antibodies against the Streptococcus pyogenes pathogen and the majority of its exotoxins during the initial regionale singlebörsen nrw of the infection. The HZI sijglebörsen recently elucidated the role of pathogen-specific antibodies and, specifically, of antibodies that can neutralise the exotoxins of S. For this purpose, they investigated plasma samples and bacterial isolates from patients suffering from this infection and compared them to samples from patients with a non-necrotising soft tissue infection caused by Streptococcus pyogenes.
This shows a previously overlooked state of serologic susceptibility in patients with NF during the earliest stages of the infection sibglebörsen is potentially linked to disease progression" Andreas Itzek says. A pre-existing antibody titer against the exotoxins released by S. However, if the immunoglobulin G therapy takes place too late and tissue necrosis is progressing, the disintegration of tissue cannot be hindered by this treatment.
HZI researchers discover protective effect of pathogen-specific antibodies in the early infection stage of necrotising fasciitis Necrotising fasciitis NF is the most severe form of tissue death caused by ndw. Andreas Itzek, Postdoc in the working group Microbial Interactions and Regionale singlebörsen nrw The HZI researchers recently elucidated the role of pathogen-specific antibodies and, specifically, of antibodies that can neutralise the exotoxins of S.
Regionale singlebörsen nrw Download press image jpg, 2. Involved Groups Microbial Interactions and Processes. Print Send per email Share.
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