This cohort will be added to the protocol via an amendment at a later stage. Phase , multicenter, international, single-arm, open-label study. Patients must have either: AND must meet the following criteria:
This cohort will be added to kreisanzeiger bad hersfeld bekanntschaften protocol via an amendment at a later stage. Phasemulticenter, international, single-arm, open-label study. Patients must have either: AND must meet the following criteria: There must be histologic verification of disease at original diagnosis or subsequent relapse.
Patient must have evaluable or measurable disease documented by radiographic criteria or bone marrow disease Examples of good dating profile names good male online dating headlines at study entry.
The malignant cells need to be CD22 surface antigen positive in either biopsy material, the bone marrow or peripheral blood by institutional standards as determined by the local immunophenotyping laboratory. See Appendix I for Performance Scales. Patient must have a life expectancy of at least 6 weeks. At least 7 days must have elapsed since the completion of cytotoxic therapy, with the exception of hydroxyurea, 6-mercaptopurine and steroids which are permitted up until 48 hours prior to initiating protocol therapy.
Süddeutsche zeitung heirats- und bekanntschaften may have süddeutsche zeitung heirats- und bekanntschaften intrathecal süddeutsche zeitung heirats- und bekanntschaften at any time prior to study entry.
Patients who relapse while receiving maintenance chemotherapy will not be required to have a waiting period before enrollment onto this study. At least 28 days must have elapsed since any süddeutsche zeitung heirats- und bekanntschaften radiation therapy.
Hematopoietic Stem Cell Transplant: At least days must have elapsed since previous allo-HSCT. Patient must have no evidence of active graft vs. Patient must not be receiving GVHD prophylaxis or treatment. At least 7 days must have elapsed since the completion of therapy with GCSF or other growth factors at the time of enrollment. At least 42 days must have elapsed after the completion of any type of immunotherapy, e. At least 3 half-lives of the antibody must have elapsed after the last dose of a monoclonal antibody ie: Patients must have been off süddeutsche zeitung heirats- und bekanntschaften infusion for at least 14 days and all drug-related toxicity must have resolved to grade 2 or lower as outlined in the inclusion and exclusion criteria.
At least 7 days or 5 drug half-lives whichever is longer must have elapsed since prior treatment with any experimental drug with the exception of monoclonal antibodies under investigation.
No residual toxicities should be observed following previous treatment. Patient has not received prior treatment with a calicheamicin-conjugated antibody e.
If the serum creatinine is greater than 1. Female patients of childbearing potential must have a negative urine or serum pregnancy test confirmed prior to enrollment.
Female patients with infants must agree not to breastfeed their infants while on this study. Male and female patients of child-bearing potential must agree to use an highly effective method of contraception approved by the süddeutsche zeitung heirats- und bekanntschaften during the study and for 90 days after the last dose of InO.
Highly effective methods of contraception include but not exclusively the following contraceptive methods: Patients with isolated extramedullary disease are excluded not applicable to lymphoma patients süddeutsche zeitung heirats- und bekanntschaften for isolated CNS-relapse voice chat list bd. The patient may not have: A requirement for vasopressors; Positive blood culture within 48 hours of study enrollment; Fever above Fever that is determined to be due to tumor burden is allowed if patients have documented negative blood cultures for at least 48 hours prior to enrollment and no concurrent signs or symptoms of active infection or hemodynamic instability.
A positive fungal culture within 30 days of study enrollment. Active fungal, viral, bacterial, or protozoal infection requiring IV or oral treatment. Chronic crophylaxis therapy to prevent infections is allowed. Patients will be excluded if there is a plan to administer non-protocol anti-cancer therapy süddeutsche zeitung heirats- und bekanntschaften but not limited to chemotherapy, radiation therapy, or immunotherapy during the study period. Patients will be excluded if they have significant concurrent disease, illness, psychiatric disorder or social issue that would compromise patient safety or compliance with protocol therapy, interfere with consent, study participation, follow up, or interpretation of study results.
Children with Down syndrome are excluded from participation in the dose finding part stratum 1Abut not in the stratum 1 phase 2 cohort.