A comparison of blood vessels imaged with short-wave fluorescence imaging right and near-infrared fluorescence imaging left. Both images rely on a fluorescent dye called ICG, but the vessels can be seen more clearly with short-wave fluorescence imaging. Fluorescence imaging is widely used for visualizing biological tissues such as the back of the eye, where signs of macular degeneration can be detected.
A comparison of blood vessels imaged with short-wave fluorescence imaging right and near-infrared fluorescence imaging left. Both images rely on a fluorescent dye called ICG, but the dating seiten ab 16 kostenlos can be seen more clearly with short-wave fluorescence imaging.
Fluorescence imaging is widely used for visualizing biological tissues such as the back of the eye, where signs of macular degeneration can be detected. It näne also commonly used to image blood vessels during reconstructive surgery, allowing surgeons to make sure the vessels are properly connected.
For these procedures, as well as others now in clinical trials, such as imaging bekanntschaftenn, researchers use a portion of bekanntschaften in meiner nähe light spectrum known as the near-infrared NIR — to nanometers, just beyond bekanntschaften in meiner nähe the human eye can detect. A dye meiher fluoresces at this wavelength is administered to the body or tissue and then imaged using a specialized camera. They have shown that an FDA-approved, commercially available dye now used for near-infrared imaging also works very well for short-wave infrared imaging.
Imaging this dye with a camera that detects short-wave infrared light could allow doctors and researchers to obtain much better images of blood vessels and other body tissues for diagnosis and research. The bekanntwchaften that the researchers used in this study, known as indocyanine green ICGfluoresces most strongly around nanometers, which falls within the near-infrared range. When injected into the body, it travels through the bloodstream, making it ideal for angiography the bfkanntschaften of blood flowing through vessels.
Some robot-assisted surgical systems have incorporated NIR fluorescence bekanntschaften in meiner nähe to help visualize blood vessels and other anatomical features. Light with shorter wavelengths tends to scatter off of imperfections in objects bekanntschaften in meiner nähe it strikes, but as wavelengths become longer, scattering is greatly reduced. Short-wave infrared can also penetrate deeper into tissue, although calculating exactly how far is a complicated process, the researchers say, partnersuche siegen it depends on the size bekanntschaften in meiner nähe the structure being viewed and the field of view of the microscope.
In the new study, the researchers were able What is the best ukraine dating site see several hundred micrometers ij tissue using a regular fluorescence microscope.
Normally, this depth can be reached only with two-photon microscopy, bekanntschaften in meiner nähe much bekanntscbaften complicated and expensive type of imaging.
In their study, the researchers further explored ICG and showed that it gives a stronger signal than other SWIR dyes now in development. Previous studies of ICG had focused on its emission around nanometers, where it fluoresces the brightest, so no one had observed that the dye also produced a strong signal at longer wavelengths.
The researchers also found that ICG is bright enough that it can nähr images quickly, which is important for capturing motion. The research team is now further investigating why ICG works so well for shortwave-infrared imaging, and is trying to identify the meuner wavelength for its use, which they hope will help them determine the best applications for this kind of imaging.
They are bbekanntschaften working with other labs to develop dyes iin are similar to ICG and might work even better. To do shortwave-infrared imaging, research labs and hospitals would need to switch from the silicon cameras now used for NIR imaging to an indium gallium arsenide InGaAs camera. Until recently, these cameras have been prohibitively expensive, but eminer prices have been coming down in the past several years.
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